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NCI Drug Dictionary

NCI Drug Dictionary

  

hydroxyurea 
A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:HYD
Hydroxycarbamide
Hydurea
US brand names:Droxia
Hydrea
Foreign brand names:Litalir
Onco-Carbide
Oxeron
Syrea
Abbreviation:HU
Code names:SQ-1089
WR 83799