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NCI Drug Dictionary

  

piroxantrone 
An anthrapyrazole antineoplastic antibiotic. Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:oxanthrazole
oxantrazole
Piroxantrone HCl
Code names:CI-942
PD-111815
Chemical structure:Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)