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NCI Drug Dictionary

  

flucytosine 
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is deaminated to its active metabolite 5-fluorouracil. 5-fluorouracil replaces uracil during fungal RNA synthesis, thereby inhibiting fungal protein synthesis. In addition, fluorouracil is further metabolized to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase, thereby interrupting nucleotide metabolism, DNA synthesis and ultimately protein synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:5-fluorocytosine
US brand name:Ancobon
Foreign brand names:Alcobon
Ancotil
Abbreviation:5-FC
Code names:Ro 2-9915
Ro-2-9915
Chemical structure:4-amino-5-fluoro-2(1H)-pyrimidinone