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NCI Drug Dictionary

  

finasteride 
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Proscar
Foreign brand names:Chibro-Proscar
Finastid
Pro-Cure
Prostide
Uprosan
Code name:MK 906
Chemical structure:(5alpha,17beta)-N-(1,1-dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide