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NCI Drug Dictionary

  

asparaginase 
An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora with antileukemic activity. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia in leukemic cells, resulting in the depletion of asparagine, inhibition of protein synthesis, cell cycle arrest in the G1 phase, and apoptosis in susceptible leukemic cell populations. Asparagine is critical to protein synthesis in leukemic cells; some leukemic cells cannot synthesize this amino acid de novo due to the absent or deficient expression of the enzyme asparagine synthase. The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:ASNase
ASP-1
asparaginase Erwinia
asparaginase II
Colaspase
L-ASP
L-asparaginase
L-asparagine amidohydrolase
US brand names:Cristanaspase
Elspar
L-Asnase
Foreign brand names:Crasnitin
Crasnitine
Erwinase
Kidrolase
Laspar
Leucogen
Leunase
Paronal
Abbreviations:L-ASP
Lcf-ASP
Code names:EC 3.5.1.1
MK-965
Re-82-TAD-15