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NCI Drug Dictionary

  

cladribine 
A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Cladribina
US brand name:Leustatin
Foreign brand names:Leustat
Leustatine
Abbreviations:2CDA
2-CdA
Code name:RWJ-26251
Chemical structures:2-chloro-2-deoxyadenosine
2-chlorodeoxyadenosine