NCI Drug Dictionary
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A platinum(IV) analogue with antineoplastic activity. Ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Chemical structure:||tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))platinum|