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NCI Drug Dictionary

NCI Drug Dictionary

  

miltefosine 
An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity. Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth. This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis. As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt
hexadecylphosphocholine
Miltefosin
Miltefosina
Miltefosinum
Foreign brand name:Miltex
Abbreviation:HDPC
Code name:D-18506
Chemical structures:2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt
Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate
n-Hexadecylphosphorylcholine