NCI Drug Dictionary
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A synthetic, nonsteroidal antiandrogen. Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Casodex|
|Foreign brand name:||Cosudex|
|Code name:||ICI 176,334|
|Chemical structures:||(+/-)-N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide |