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NCI Drug Dictionary

  

theophylline 
A natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Physiologically, this agent relaxes bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:theophylline monohydrate
US brand names:Constant-T
Elixophyllin
LaBID
Respbid
Slo-bid
Slo-Phyllin
Somophyllin-CRT
Somophyllin-T
Theo-24
Theobid Duracap
Theochron
T-Phyl
Uniphyl
Chemical structures:1,3-dimethylxanthine monohydrate
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione
3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione monohydrate