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NCI Drug Dictionary

NCI Drug Dictionary

  

mifamurtide 
A liposomal formulation containing a muramyl dipeptide (MDP) analogue with potential immunomodulatory and antineoplastic activities.. Muramyl tripeptide phosphatidylethanolamine (MTP-PE), a derivative of the mycobacterial cell wall component MDP, activates both monocytes and macrophages. Activated macrophages secrete cytokines and induce the recruitment and activation of other immune cells, which may result in indirect tumoricidal effects. Liposomal encapsulation of MTP-PE prolongs its half-life and enhances tissue targeting. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:CGP 19835A Lipid
muramyl tripeptide phosphatidylethanolamine liposome
US brand name:JUNOVAN
Foreign brand name:MEPACT
Abbreviations:L-MTP-PE
MTP-PE Liposome