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NCI Drug Dictionary

NCI Drug Dictionary

  

eculizumab 
A human monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Alexion
monoclonal antibody 5G1.1
monoclonal antibody anti-C5
US brand name:Soliris
Abbreviation:h5G1.1