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NCI Drug Dictionary

NCI Drug Dictionary

  

procarbazine hydrochloride  Patient Information
The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Ibenzmethyzin
ibenzmethyzin hydrochloride
ibenzmethyzine hydrochloride
MIH
MIH hydrochloride
PCB Hydrochloride
PCZ
Procarbazin
US brand name:Matulane
Foreign brand names:Natulan
Natulanar
Natunalar
Abbreviations:PCB
PCZ
Code names:NCI-C01810
Ro 4-6467/1
Chemical structures:benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)
N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride
N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine hydrochloride
N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride
N-methylhydrazine
p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride
p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)