NCI Drug Dictionary
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The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Matulane|
|Foreign brand names:||Natulan |
|Code names:||NCI-C01810 |
|Chemical structures:||benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI) |
p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)