NCI Drug Dictionary
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An antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Abitrexate |
|Foreign brand names:||Brimexate |
|Code names:||CL-14377 |
|Chemical structures:||4-amino-10-methylfolic acid |