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NCI Drug Dictionary

NCI Drug Dictionary

  

formestane 
A synthetic steroidal substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:4-hydroxyandrostenedione
Foreign brand name:Lentaron
Abbreviations:4-OHA
4-OHAD
Code name:CGP-32349
Chemical structure:4-Hydroxyandrost-4-ene-3,17-dione