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NCI Drug Dictionary

  

busulfan  Patient Information
A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties. Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA. Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:BSF
Bussulfam
Busulfanum
busulphan
glyzophrol
methanesulfonic acid, tetramethylene ester
Myeleukon
Myeloleukon
Myelosan
Mylecytan
Sulfabutin
tetramethylene bis(methanesulfonate)
US brand names:Busulfex
Myleran
Foreign brand names:Mielucin
Misulban
Misulfan
Mitosan
Abbreviations:BU
BUS
Code names:CB-2041
GT-41
WR-19508
Chemical structures:1,4-bis(methanesulfonoxy)butane
1,4-bitanediol dimethanesulfonate esters
1,4-butanediol dimethylsulfonate
1,4-di(methanesulfonyloxy)butane
1,4-di(methylsulfonyloxy)butane