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NCI Drug Dictionary

  

eltrombopag olamine  Patient Information
The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Promacta
Code names:SB 497115
SB497115
SB-497115