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NCI Drug Dictionary

NCI Drug Dictionary

  

O6-benzylguanine 
A guanine analogue with antineoplastic activity. O(6)-benzylguanine binds the DNA repair enzyme O(6)-alkylguanine DNA alkyltransferase (AGT), transferring the benzyl moiety to the active-site cysteine and resulting in inhibition of AGT-mediated DNA repair. Co-administration of this agent potentiates the effects of other chemotherapeutic agents that damage DNA. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Abbreviation:BG