NCI Drug Dictionary
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An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Orplatna|
|Code names:||BMS-182751 |
|Chemical structures:||(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum |