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NCI Drug Dictionary

NCI Drug Dictionary

  

alitretinoin 
An orally- and topically-active naturally-occurring retinoic acid with antineoplastic, chemopreventive, teratogenic, and embryotoxic activities. Alitretinoin binds to and activates nuclear retinoic acid receptors (RAR) and retinoid X receptors (RXR); these activated receptors act as transcription factors, regulating gene expression that results in the inhibition of cell proliferation, induction of cell differentiation, and apoptosis of both normal cells and tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:9-cis-retinoic acid
US brand name:Panretin
Foreign brand names:Panretyn
Panrexin
Abbreviation:9-CRA
Acronym:9-cis-RA
Code names:ALRT1057
LGD1057
Chemical structures:3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid