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NCI Drug Dictionary


A benzotriazine di-N-oxide with potential antineoplastic activity. Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Tirazone
Code names:SR 4233
WIN 59075
Chemical structure:3-amino-1,2,4-benzotriazine-1,4-dioxide