NCI Drug Dictionary
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A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand name:||Arava|
|Chemical structure:||4-isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl)-|