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NCI Drug Dictionary


human papillomavirus 16 E7 peptide 
A synthetic peptide sequence of human papillomavirus (HPV) E7 nuclear protein which is used to produce vaccines against HPV infection and HPV-related neoplasms. HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator. This protein is important in the induction and maintenance of cellular transformation and is co-expressed in the majority of HPV-containing carcinomas. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:HPV16 E7
HPV-16 E7