In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

NCI Drug Dictionary

  

denileukin diftitox  Patient Information
A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:DAB(389)-interleukin-2
DAB389 interleukin-2
DAB389 interleukin-2 immunotoxin
DABIL2
US brand name:ONTAK
Abbreviations:DAB389IL2
DAB389-IL2
DAB389IL-2
Code name:LY335348