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A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||dihydrocuminyl alcohol |
|Chemical structures:||(S)-(-)-perillyl alcohol |