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NCI Drug Dictionary

NCI Drug Dictionary

  

perillyl alcohol 
A naturally occurring monoterpene related to limonene with antineoplastic activity. Perillyl alcohol inhibits farnesyl transferase and geranylgeranyl transferase, thereby preventing post-translational protein farnesylation and isoprenylation and activation of oncoproteins such as p21-ras, and arresting tumor cells in the G1 phase of the cell cycle. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:dihydrocuminyl alcohol
perilla alcohol
perillic alcohol
perillol
Abbreviation:POH
Chemical structures:(S)-(-)-perillyl alcohol
1-cyclohexene-1-methanol
4-(1-methylethenyl)-1-cyclohexene-1-methanol
4-isopropenylcyclohex-1-ene-1-methanol
p-mentha-1,8-dien-7-ol