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NCI Drug Dictionary

NCI Drug Dictionary

  

oxaliplatin  Patient Information
An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane (DACH) and with an oxalate ligand as a 'leaving group.' A 'leaving group' is an atom or a group of atoms that is displaced as a stable species taking with it the bonding electrons. After displacement of the labile oxalate ligand leaving group, active oxaliplatin derivatives, such as monoaquo and diaquo DACH platinum, alkylate macromolecules, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. The DACH side chain appears to inhibit alkylating-agent resistance. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:diaminocyclohexane oxalatoplatinum
oxalatoplatin
oxalatoplatinum
US brand name:Eloxatin
Foreign brand names:Dacotin
Dacplat
Eloxatine
Abbreviations:1-OHP
L-OHP
Code names:JM-83
RP-54780
SR-96669
Chemical structures:[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum
[SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum
oxalato (1R,2R-cyclohexanediamine)platinum(II)
oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)
trans-l DACH oxalatoplatinum
trans-l diaminocyclohexane oxalatoplatinum