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NCI Drug Dictionary


A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
therapeutic dehydroepiandrosterone
US brand name:Fidelin
Code name:GL701
Chemical structure:3beta-Hydroxyandrost-5-en-17-one