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A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties. Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|US brand names:||Camptogen |
|Code name:||RFS 2000|
|Chemical structure:||9-nitro-20 (S-)camptothecin|