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NCI Drug Dictionary

  

penicillamine 
A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Depamine
D-mercaptovaline
D-Penicillamine
US brand names:Cuprenil
Cuprimine
Depen
Perdolat
Sufortan
Foreign brand names:Atamir
Cupripen
Distamine
Kelatin
Mercaptyl
Metalcaptase
Pendramine
Trolovol
Chemical structures:3-mercapto-D-valine
alpha-amino-beta-methyl-beta-mercaptobutyric acid
beta,beta-dimethylcysteine
beta-thiovaline