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NCI Drug Dictionary

  

isotretinoin 
A naturally-occurring retinoic acid with potential antineoplastic activity. Isotretinoin binds to and activates nuclear retinoic acid receptors (RARs); activated RARs serve as transcription factors that promote cell differentiation and apoptosis. This agent also exhibits immunomodulatory and anti-inflammatory responses and inhibits ornithine decarboxylase, thereby decreasing polyamine synthesis and keratinization. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:13-cis-retinoic acid
13-cis-vitamin A acid
cis-retinoic acid
isotretinoinum
neovitamin A
Neovitamin A Acid
US brand names:Accutane
Amnesteem
Cistane
Claravis
Sotret
Foreign brand names:Accure
Isotrex
Isotrexin
Oratane
Roaccutan
Roaccutane
Roacutan
Abbreviation:13-CRA
Code name:Ro 4-3780
Chemical structures:3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid