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NCI Drug Dictionary

NCI Drug Dictionary

  

mitomycin C  Patient Information
A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species. Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:mitomycine C
mitomycin-X
US brand names:Mitozytrex
Mutamycin
Foreign brand names:Ametycine
Mitocin-C
Mitolem
Mito-Medac
Mutamycine
Abbreviations:MITC
MITO
MITO-C
MTC
Code name:NCI-C04706
Chemical structures:(1aS,8S,8aR,8bS)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
[1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione