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NCI Drug Dictionary

NCI Drug Dictionary

  

LMB-7 immunotoxin 
A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells. The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:B3(Fv)-PE38
B3(Fv)-PE38 Immunotoxin
HB21(Fv)PE40
immunotoxin LMB-7
LMB-7 (Single-Chain Immunotoxin)