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NCI Drug Dictionary

NCI Drug Dictionary

  

etoposide phosphate  Patient Information
A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Etopophos
Abbreviation:ETOP