In English | En español
Questions About Cancer? 1-800-4-CANCER

NCI Drug Dictionary

  

streptozocin 
A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes. Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis. Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations. Unlike other nitrosoureas, streptozocin causes little myelosuppression. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:streptozotocin
US brand name:Zanosar
Abbreviations:STZ
SZC
SZN
Code name:U-9889
Chemical structures:2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose