NCI Drug Dictionary
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A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin. In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody |
|US brand name:||Mylotarg|
|Code names:||CDP-771 |