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NCI Drug Dictionary

  

testolactone 
A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Fludestrin
therapeutic testolactone
US brand name:Teslac
Abbreviation:TL
Code name:SQ-9538
Chemical structures:1,2,3,4,4a,4b,7,9,10,10a-decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone
13-hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone
17alpha-oxo-D-homo-1,4-androstadiene-3,17-dione
1-dehydrotestololactone
delta-1-testololactone
D-homo-17a-oxaandrosta-1,4-diene-3,17-dione