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NCI Drug Dictionary

NCI Drug Dictionary

  

recombinant flt3 ligand 
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine Flt3. Flt3 ligand binds to the Flt3 tyrosine kinase receptor and, synergistically with other growth factors, stimulates the proliferation and mobilization of certain bone marrow precursor cells, including CD34+ cells, and dendritic cells. When proteolytically cleaved, the transmembrane isoform of Flt3 ligand generates the soluble form soluble Flt3 ligand , which is also biologically active. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:flt3 ligand
rhuFlt3L
US brand name:Mobista
Abbreviation:rFlt3L
Code name:CDX-301