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NCI Drug Dictionary

NCI Drug Dictionary

  

thiotepa 
A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:thiophosphamide
thiophosphoramide
triethylene thiophosphoramide
US brand names:Girostan
STEPA
TESPA
Thiofozil
Thioplex
Tifosyl
Foreign brand names:Ledertepa
Onco Tiotepa
Oncotiotepa
Tespamin
Tespamine
Thiotef
Tio-TEF
Abbreviation:TSPA
Code name:WR 45312
Chemical structures:1,1',1"-phosphinothioylidynetrisaziridine
1,1',1''-phosphinothioyldynetrisaziridine
N,N',N''-triethylenethiophosphoramide
tris(1-aziridinyl)phosphine sulfide