NCI Drug Dictionary
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A polyfunctional, organophosphorus alkylating agent and a stable derivative of N,N',N''-triethylenephosphoramide (TEPA), with antineoplastic activity. Upon administration, thiotepa is converted into highly reactive ethylenimine groups, which covalently bind to nucleophilic groups in DNA and demonstrate a preference for the N7 position of guanine bases. This induces crosslinking of alkylated guanine bases in double-stranded DNA, interferes with both DNA replication and cell division, and results in both the induction of apoptosis and the inhibition of cell growth. Check for active clinical trials or closed clinical trials using this agent.
|Foreign brand name:||tepadina|
|Code name:||WR 45312|
|Chemical structures:||1,1',1"-phosphinothioylidynetrisaziridine |