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NCI Drug Dictionary

  

Ad5CMV-p53 gene 
A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Adeno-p53
Adenovirus p53
US brand name:ADVEXIN
Abbreviations:Ad5CMV-p53
Ad-p53
Code names:INGN-201
RPR/INGN-201