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NCI Drug Dictionary

NCI Drug Dictionary

  

carmustine  Patient Information
An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:bis(chloroethyl) nitrosourea
bis-chloronitrosourea
carmustin
US brand names:Becenum
BiCNU
Carmubris
Foreign brand names:Becenun
Carmustinum
Nitrourean
Nitrumon
Abbreviation:BCNU
Code names:FDA 0345
SK 27702
SRI 1720
WR-139021
Chemical structures:1,3-bis(2-chloroethyl)-1-nitrosourea
1,3-bis(beta-chloroethyl)-1-nitrosourea
N,N'-bis(2-chloroethyl)-N-nitrosourea