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NCI Drug Dictionary

  

lomustine  Patient Information
A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis. This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing. Lomustine is lipophilic and crosses the blood-brain barrier. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Lomustinum
US brand name:CeeNU
Foreign brand names:Belustin
Belustine
Cecenu
Citostal
Lomeblastin
Lucostin
Lucostine
Prava
Abbreviation:CCNU
Acronym:CCNU
Code names:RB-1509
WR-139017
Chemical structures:1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chloroethylcyclo-hexylnitrosourea
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea