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A small-molecule arsenic compound with antineoplastic activity. The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonyms:||Arsenic (III) Oxide |
Arsenous Acid Anhydride
|US brand name:||Trisenox|