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NCI Drug Dictionary

NCI Drug Dictionary

  

acitretin 
An orally-active metabolite of the synthetic aromatic retinoic acid agent etretinate with potential antineoplastic, chemopreventive, anti-psoratic, and embryotoxic properties. Acitretin activates nuclear retinoic acid receptors (RAR), resulting in induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. This agent may also inhibit tumor angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:Trimethylmethoxyphenyl-retinoic acid
US brand names:Etretin
Soriatane
Foreign brand name:Neotigason
Code names:Ro 10-1670
Ro-10-1670
Chemical structure:(All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid