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NCI Drug Dictionary

  

nelarabine  Patient Information
An arabinonucleoside antimetabolite with antineoplastic activity. Nelarabine is demethoxylated by adenosine deaminase to become biologically active 9-beta-D-arabinosylguanine (ara-G); ara-G incorporates into DNA, thereby inhibiting DNA synthesis and inducing an S phase-dependent apoptosis of tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
US brand name:Arranon
Code names:506U78
GW506U78
Chemical structures:2-amino-6-methoxypurine arabinoside
2-amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine