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NCI Drug Dictionary


A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Lucatumumab binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonym:monoclonal antibody CHIR-12.12
Abbreviation:MOAB CHIR-12.12
Code names:CHIR-12.12
Chemical structure:immunoglobulin G1, anti-(human CD40 (antigen)) (human monoclonal CHIR-12.12 heavy chain), disulfide with human monoclonal CHIR-12.12 light chain, dimer