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NCI Drug Dictionary

NCI Drug Dictionary

  

ingenol 3-angelate 
A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol 3-angelate (I3A) activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:3-ingenyl angelate
ingenol mebutate
Abbreviation:I3A
Code name:PEP005