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NCI Drug Dictionary

NCI Drug Dictionary

  

prednisolone 
A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:delta(1)hydrocortisone
delta1-dehydro-hydrocortisone
deltahydrocortisone
metacortandralone
US brand names:Cortalone
Delta-Cortef
Hydeltra
Hydeltrasol
Meti-derm
Prelone
Foreign brand names:Adnisolone
Aprednislon
Capsoid
Cortisolone
Dacortin H
Decaprednil
Decortin H
Delta- Cortef
Deltacortril
Delta-Diona
Delta-Phoricol
Deltasolone
Deltidrosol
Dhasolone
Di-Adreson-F
Dontisolon D
Estilsona
Fisopred
Frisolona
Gupisone
Hostacortin H
Klismacort
Kuhlprednon
Lenisolone
Lepi-Cortinolo
Linola-H N
Linola-H-Fett N
Longiprednil
Meticortelone
Opredsone
Panafcortelone
Precortisyl
Pred-Clysma
Predeltilone
Predni-Coelin
Prednicortelone
Predni-Helvacort
Prenilone
Abbreviation:PRDL
Chemical structures:(11beta)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione
1,2-dehydrohydrocortisone