NCI Drug Dictionary
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A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity. Vadimezan induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis. This agent also stimulates the anti-tumor activity of tumor-associated macrophages. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
|Synonym:||Dimethyloxoxanthene Acetic Acid|
|Code names:||AS1404 |
|Chemical structure:||5,6-Dimethylxanthenone-4-Acetic Acid|