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NCI Drug Dictionary


BL22 immunotoxin 
A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity. BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells. The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
Synonyms:Anti-CD22 Recombinant Immunotoxin BL22
BL22 Immunotoxin [RFB4(dsFv) - PE38
RFB4(dsFv)-PE38 immunotoxin
Code name:CAT-3888