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NCI Drug Dictionary

NCI Drug Dictionary

  

AFP gene hepatocellular carcinoma vaccine 
A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma. This agent exerts an antitumor effect by inducing cytotoxic T-lymphocytes to attack AFP-expressing tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)